4-Phenoxybenzoyl chloride → 2-Fluoro-6-(4-phenoxy-benzoylamino)-benzoic acid

HRID 1669979

Reaction equation

HRID 1669979 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[O:12]([C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[F:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:2]([NH:1][C:23](=[O:24])[C:22]2[CH:21]=[CH:20][C:19]([O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:27][CH:26]=2)[C:3]=1[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 741934-Phenoxybenzoyl chlorideHCID 5211422-Amino-6-fluorobenzoic acid

Product 1

HCID 119905412-Fluoro-6-(4-phenoxy-benzoylamino)-benzoic acid

Procedure

In analogy to example 1,2-Fluoro-6-(4-phenoxy-benzoylamino)-benzoic acid was prepared from 2-amino-6-fluoro-benzoic acid and 4-phenoxy-benzoyl chloride [1623-95-6]. MS (m/e): 350.1 (M−H−, 100%).

Sources & evidence

ORD record
ord-05341340833e48309f1ebd9c2d18c254
Source dataset
uspto-grants-2011_08
Patent number
US07989657B2

Linked notes

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