(2R)-N-methanesulfonyl-(4-chlorophenyl)alanine → 1-(1,1-Dimethylethyl) 1,2-aziridinedicarboxylate

Reaction equation

CS(N(C1C=CC(Cl)=CC=1)[C@@H](C(O)=O)C)(=O)=O.[C:18]([N:25]1[CH2:27][CH:26]1[C:28]([O:30]C)=[O:29])([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]>>[C:18]([N:25]1[CH2:27][CH:26]1[C:28]([OH:30])=[O:29])([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]

Participants

Reactant 2

HCID 967528(2R)-N-methanesulfonyl-(4-chlorophenyl)alanine

HCID 111716531-Tert-butyl 2-methyl aziridine-1,2-dicarboxylate

Product 1

HCID 210259561-(1,1-Dimethylethyl) 1,2-aziridinedicarboxylate

Procedure

The title compound was prepared following the procedure described in Step B of Intermediate 135 using methyl 1-BOC-2-aziridinecarboxylate prepared in Step B.

Sources & evidence

ORD record: ord-5fd1222b6cd146f39535fc8674f68235
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989634B2

Reaction notes

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