2-chloro-N-(2-phenylethyl)propanamide → HCID 57437916, compound
Reaction equation
Cl[CH:2]([CH3:14])[C:3]([NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4].[Cl-].[Cl-].[Cl-].[Al+3]>O.CO>[CH3:14][CH:2]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6][NH:5][C:3]1=[O:4]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 150 °C
Procedure
8.0 g (37 mmol) 2-chloro-N-(2-phenylethyl)-propanamide and 15 g (112 mmol) aluminium trichloride are carefully mixed at 90° C. and heated to 150° C. for 6 h. The mixture is diluted with water and methanol and extracted with EtOAc. The combined organic phases are dried with Na2SO4, concentrated i. vac. and purified by chromatography.
Workup
- extractionextracted with EtOAc
- dry with materialThe combined organic phases are dried with Na2SO4
- concentrationconcentrated i
- customand purified by chromatography
Sources & evidence
- ORD record
- ord-b8e66e1a7fa8451e91c97e6352ae81b8
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08003639B2
Reaction notes
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