4-Fluoroanisole → 5-Fluoro-2-methoxybenzene-1-sulfonyl chloride

HRID 1675623

Reaction equation

HRID 1675623 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[Cl:10][S:11](O)(=[O:13])=[O:12]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([S:11]([Cl:10])(=[O:13])=[O:12])[CH:3]=1

Participants

3

Reactant 2

HCID 99874-FluoroanisoleHCID 24638Chlorosulfonic acid

Product 1

HCID 27834095-Fluoro-2-methoxybenzene-1-sulfonyl chloride

Procedure

4-Fluoroanisole (10.0 g) was carefully added to chlorosulphonic acid (45.81 g) at 0° C. The mixture was stirred at RT for 2 h, then quenched with ice-water (500 ml) and the solid filtered and dried, yield 16.50 g.

Workup

  1. customquenched with ice-water (500 ml)
  2. filtrationthe solid filtered
  3. customdried

Sources & evidence

ORD record
ord-f4c08e0fa871485eb64cd4a4f57de450
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Linked notes

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