Furosemide → Cetyltrimethylammonium 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzoate

HRID 1676934

Reaction equation

HRID 1676934 reaction equation
[CH:1]1[CH:2]=[C:3]([CH2:6][NH:7][C:8]2[C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]([S:17]([NH2:20])(=[O:19])=[O:18])=[C:10]([Cl:21])[CH:9]=2)[O:4][CH:5]=1.[OH-].[CH2:23]([N+:39]([CH3:42])([CH3:41])[CH3:40])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38]>O>[NH2:20][S:17]([C:11]1[C:10]([Cl:21])=[CH:9][C:8]([NH:7][CH2:6][C:3]2[O:4][CH:5]=[CH:1][CH:2]=2)=[C:13]([CH:12]=1)[C:14]([O-:16])=[O:15])(=[O:18])=[O:19].[CH2:23]([N+:39]([CH3:42])([CH3:40])[CH3:41])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38]

Participants

4

Reactant 2

HCID 3440FurosemideHCID 68166Cetrimonium Hydroxide

Product 1

HCID 11592520Cetyltrimethylammonium 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzoate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In similar manner to Example 10, furosemide can be reacted with cetyltrimethylammonium hydroxide in water to yield cetyltrimethylammonium 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzoate.

Sources & evidence

ORD record
ord-4d7ef736fcd54f5c95c9d72b40b12987
Source dataset
uspto-grants-2011_08
Patent number
US08008283B2

Linked notes

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