2-(4-Chlorophenyl)ethylamine → HCID 57571688, compound
Reaction equation
C[C:2]1[C:3](Cl)=[N:4][C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[Cl:13][C:14]1[CH:22]=[CH:21][C:17]([CH2:18][CH2:19][NH2:20])=[CH:16][CH:15]=1.[C:23]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24]>>[C:26]([O:25][C:23]([N:30]1[CH2:35][CH2:34][N:33]([C:3]2[CH:2]=[CH:10][C:6]([C:7](=[O:9])[NH:20][CH2:19][CH2:18][C:17]3[CH:21]=[CH:22][C:14]([Cl:13])=[CH:15][CH:16]=3)=[C:5]([Cl:11])[N:4]=2)[CH2:32][CH2:31]1)=[O:24])([CH3:29])([CH3:27])[CH3:28]Participants
4
Procedure
In analogy to example 38 methyl 2,6-dichloronicotinic acid was coupled with 4-chlorophenethylamine and then reacted with N-Boc-piperazine. Light yellow solid.
Sources & evidence
- ORD record
- ord-a5c89b80fe854013874d7dedb65a15b4