4-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile → HCID 16749887, compound

HRID 1677654

Reaction equation

HRID 1677654 reaction equation
[CH:1]1[N:5]=[CH:4][N:3]2[CH2:6][CH:7]=[C:8]([C:9]3[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=3)[C:2]=12>CO.[Pd]>[CH:1]1[N:5]=[CH:4][N:3]2[CH2:6][CH2:7][CH:8]([C:9]3[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=3)[C:2]=12

Participants

4

Reactant 1

HCID 669338694-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile

Product 1

HCID 16749887HCID 16749887, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 0.99 mmol of 4-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile in 15 ml of MeOH is hydrogenated in the presence of 123 mg of 10% Pd/C at room temperature for 5.5 hours. The reaction mixture is subjected to clarifying filtration and the filtrate is evaporated. From the residue the title compound is obtained by means of flash chromatography (SiO2 60F) as a-pale reddish solid. Rf=0.22 (dichloromethane/ammonia (2M in EtOH) 97:3), Rt=4.43 (Gradient I).

Workup

  1. filtrationfiltration
  2. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-00dad5054bce4742a03a1d72cf2f63cb
Source dataset
uspto-grants-2011_08
Patent number
US08008334B2

Linked notes

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