Ammonium Chloride → 4-Amino-7-(trifluoromethyl)quinoline

HRID 1678308

Reaction equation

HRID 1678308 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[Cl-].[NH4+:17]>CO>[NH2:17][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 676684-Chloro-7-(trifluoromethyl)quinoline

Product 1

HCID 27359604-Amino-7-(trifluoromethyl)quinoline

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-chloro-7-trifluoromethylquinoline (1 g) and ammonium chloride (1 g) in methanol (10 mL) was heated at 70° C. overnight. Then the solid was filtered off and washed with methanol. The filtrated was evaporated to give 4-amino-7-trifluoromethylquinoline. LCMS: ret. time: 14.81 min.; purity: 82.25%; MS (m/e): 228.11 (M+16).

Workup

  1. filtrationThen the solid was filtered off
  2. washwashed with methanol
  3. customThe filtrated was evaporated

Sources & evidence

ORD record
ord-2299b1780c344cf68e6af34e073ce4f6
Source dataset
uspto-grants-2011_08
Patent number
US08008501B2

Linked notes

Loading…