5'-tert-Butoxycarbonylamino-2'-trifluoromethoxy-biphenyl-4-carboxylic acid ethyl ester → 5'-tert-Butoxycarbonylamino-2'-trifluoromethoxy-biphenyl-4-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH:15]=[CH:14][C:13]=2[O:26][C:27]([F:30])([F:29])[F:28])=[CH:8][CH:7]=1)=[O:5])C>C(O)C.[OH-].[Na+]>[C:22]([O:21][C:19]([NH:18][C:16]1[CH:15]=[CH:14][C:13]([O:26][C:27]([F:28])([F:29])[F:30])=[C:12]([C:9]2[CH:10]=[CH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][CH:8]=2)[CH:17]=1)=[O:20])([CH3:25])([CH3:23])[CH3:24]Participants
4
Procedure
5′-tert-Butoxycarbonylamino-2′-trifluoromethoxy-biphenyl-4-carboxylic acid ethyl ester (200 mg) in ethanol (7 ml) and 2M sodium hydroxide (4 ml) was stirred at 20 C for 18 h. The ethanol was then evaporated and the residue acidified. The solid thus formed was collected by filtration and dried (128 mg)