HCID 19382157, compound → 3-Aminomethyl-1-benzyl-3-methoxy-pyrrolidine
Reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][C:10]([C:15]#[N:16])([O:13][CH3:14])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Ni]>[NH2:16][CH2:15][C:10]1([O:13][CH3:14])[CH2:11][CH2:12][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:9]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
The solution of 26.5 g (0.11 mol, 93% proof) 1-benzyl-3-cyano-3-methoxypyrrolidine in 300 ml methanol is hydrogenated at 15 g Raney-Ni at 60° C./100 bar H2. The catalyst is removed by filtration, the methanol is removed in vacuo, and the residue is distilled.
Workup
- customThe catalyst is removed by filtration
- customthe methanol is removed in vacuo
- distillationthe residue is distilled
Sources & evidence
- ORD record
- ord-2757cbe2495943eaa2ba27d3eba53ede
- Source dataset
- uspto-grants-1992_12
- Patent number
- US05173484
Reaction notes
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