Ammonia → HCID 54235505, compound

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)([C:14](O)=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:23]>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][C:11]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)([C:14]([NH2:23])=[O:15])[CH2:12][CH2:13]1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

Reactant 2

HCID 222Ammonia

HCID 545671911-(tert-Butoxycarbonyl)-4-(pyridin-4-yl)piperidine-4-carboxylic acid

Product 1

HCID 54235505HCID 54235505, compound

Procedure

Prepare by the method of example 20.8 using 1-tert-butoxycarbonyl-4-(pyridin-4-yl)-piperidine-4-carboxylic acid (4.0 mmol) and NH3 (gas). Purify to give the title compound.

Workup

customPurify

Sources & evidence

ORD record: ord-5d3c02d18d0d4aa7b47c606e4279b0c8
Source dataset: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05635510

Reaction notes

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