8-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one → 2-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino)-pyrimidin-4-ylamino]-3,5-difluoro-N-methyl-benzamide

HRID 168306Notes

Reaction equation

HRID 168306 reaction equation
[Cl:14][c:15]1[n:16][cH:17][c:18]([Cl:34])[c:19]([NH:21][c:22]2[c:23]([C:24](=[O:25])[NH:26][CH3:27])[cH:28][c:29]([F:33])[cH:30][c:31]2[F:32])[n:20]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[NH:7][C:8](=[O:12])[CH2:9][CH2:10][CH2:11]2>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[NH:7][C:8](=[O:12])[CH2:9][CH2:10][CH2:11]2)[c:15]1[n:16][cH:17][c:18]([Cl:34])[c:19]([NH:21][c:22]2[c:23]([C:24](=[O:25])[NH:26][CH3:27])[cH:28][c:29]([F:33])[cH:30][c:31]2[F:32])[n:20]1

Participants

3

Reactant 2

HCID 46151688-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-oneHCID 866339982-(2,5-Dichloro-pyrimidin-4-ylamino)-3,5-difluoro-N-methyl-benzamide

Product 1

HCID 668304722-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino)-pyrimidin-4-ylamino]-3,5-difluoro-N-methyl-benzamide

Sources & evidence

ORD record
ord-68c1774a1db5413bb4ce4fb35d68836f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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