Diethyl Ether → 3-Dipropylamino-5-isopropenylchroman

Reaction equation

[CH2:1]([N:4]([CH2:18][CH2:19][CH3:20])[CH:5]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[C:15](=O)[CH3:16])[O:7][CH2:6]1)[CH2:2][CH3:3].[CH2:21](OCC)C>>[CH2:1]([N:4]([CH2:18][CH2:19][CH3:20])[CH:5]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[C:15]([CH3:21])=[CH2:16])[O:7][CH2:6]1)[CH2:2][CH3:3]

Participants

Reactant 2

HCID 3283Diethyl Ether

HCID 102212133-Dipropylamino-5-acetylchroman

Product 1

HCID 190282133-Dipropylamino-5-isopropenylchroman

Procedure

3-Dipropylamino-5-acetylchroman (Example 7; 0.40 g, 1.45 mmol) was dissolved in dry diethyl ether (2.0 ml) and this solution was added to the previously formed Wittig-reagent.

Workup

additionthis solution was added to the previously formed Wittig-reagent

Sources & evidence

ORD record: ord-723210c71eba4d9e8254adc6a1a81084
Source dataset: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05639772

Reaction notes

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