1-Pyrrolidineethanamine → 3-Fluoro-5-morpholin-4-yl-N-[4-({2-[(2-pyrrolidin-1-ylethyl)amino]pyrimidin-4-yl}oxy)-1-naphthyl]benzamide

HRID 168445

Reaction equation

HRID 168445 reaction equation
[F:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[NH:7][c:8]2[cH:9][cH:10][c:11]([O:18][c:19]3[n:20][c:21]([S:25]([CH3:26])(=[O:27])=[O:28])[n:22][cH:23][cH:24]3)[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]23)[cH:29][c:30]([N:32]2[CH2:33][CH2:34][O:35][CH2:36][CH2:37]2)[cH:31]1.[N:38]1([CH2:43][CH2:44][NH2:45])[CH2:39][CH2:40][CH2:41][CH2:42]1>>[F:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[NH:7][c:8]2[cH:9][cH:10][c:11]([O:18][c:19]3[n:20][c:21]([NH:45][CH2:44][CH2:43][N:38]4[CH2:39][CH2:40][CH2:41][CH2:42]4)[n:22][cH:23][cH:24]3)[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]23)[cH:29][c:30]([N:32]2[CH2:33][CH2:34][O:35][CH2:36][CH2:37]2)[cH:31]1

Participants

3

Reactant 2

HCID 13441-PyrrolidineethanamineHCID 595530953-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide

Product 1

HCID 595534533-Fluoro-5-morpholin-4-yl-N-[4-({2-[(2-pyrrolidin-1-ylethyl)amino]pyrimidin-4-yl}oxy)-1-naphthyl]benzamide

Sources & evidence

ORD record
ord-ef2a7304266143c0a7ac9b91b11e5b74
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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