Dihydro-3(2H)-thiophenone → Methyl 2-[3-fluoro-4-(3-oxothiolan-2-ylidenemethyl)phenyl]propionate

HRID 1685828Notes

Reaction equation

HRID 1685828 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]([CH3:15])[C:11]([O:13][CH3:14])=[O:12])[CH:5]=[CH:6][C:7]=1[CH:8]=O.[O:16]=[C:17]1[CH2:21][CH2:20][S:19][CH2:18]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:10]([CH3:15])[C:11]([O:13][CH3:14])=[O:12])[CH:5]=[CH:6][C:7]=1[CH:8]=[C:18]1[C:17](=[O:16])[CH2:21][CH2:20][S:19]1

Participants

3

Reactant 2

HCID 61252Dihydro-3(2H)-thiophenoneHCID 86639394Methyl 2-(3-fluoro-4-formylphenyl)propionate

Product 1

HCID 67265349Methyl 2-[3-fluoro-4-(3-oxothiolan-2-ylidenemethyl)phenyl]propionateYield 52.4%

Procedure

By using methyl 2-(3-fluoro-4-formylphenyl)propionate (1.05 g) obtained in Example 58 and 3-oxothiolane (1.02 g), the title compound (770 mg, 52%) was obtained in the same manner as that of Example 1.

Sources & evidence

ORD record
ord-d67e88418b524395bf74a814430d1a80
Source dataset
uspto-grants-2012_04
Patent number
US08148421B2

Reaction notes

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