1,3-Diiodopropane → HCID 178503588, compound

HRID 16930

Reaction equation

HRID 16930 reaction equation
[CH3:1][N:2]1[C:10]2[C:6]([N:7]=[CH:8][N:9]=2)=[C:5]([S:11][CH3:12])[N:4]=[CH:3]1.[I:13][CH2:14][CH2:15][CH2:16]I>>[I-:13].[I:13][CH2:14][CH2:15][CH2:16][N:7]1[C:6]2[C:5]([S:11][CH3:12])=[NH+:4][CH2:3][N:2]([CH3:1])[C:10]=2[N:9]=[CH:8]1

Participants

3

Reactant 2

HCID 123141,3-DiiodopropaneHCID 2488683-Methyl-6-methylthiopurine

Product 1

HCID 178503588HCID 178503588, compoundYield 28%

Conditions

Temperature
120 °C

Procedure

A pressure tube, equipped with a magnetic stirring bar, was charged with Compound 2 (0.54 g, 3 mmole) and 1,3-diiodopropane (2.66 g, 9 mmole). The mixture was heated to ˜120° C. for 3 hours. The residue was extensively washed with ethyl acetate and diethyl ether and dried under vacuum to give 0.4 g of yellow solid Compound 3 (yield ˜28%).

Workup

  1. customA pressure tube, equipped with a magnetic stirring bar
  2. washThe residue was extensively washed with ethyl acetate and diethyl ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-462658577d844d109c373b1b32a7fd9e
Source dataset
uspto-grants-2010_06
Patent number
US07737281B2

Linked notes

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