4-Carboxyphenylboronic Acid → 2'-(Carboxymethoxy)-5'-chlorobiphenyl-4-carboxylic acid

Reaction equation

C([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1Br)(C)(C)C.[C:18]([C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1)([OH:20])=[O:19]>>[C:6]([CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:24]1[CH:25]=[CH:26][C:21]([C:18]([OH:20])=[O:19])=[CH:22][CH:23]=1)([OH:5])=[O:17]

Participants

Reactant 2

HCID 3121834-Carboxyphenylboronic Acid

HCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

Product 1

HCID 114722872'-(Carboxymethoxy)-5'-chlorobiphenyl-4-carboxylic acid

Procedure

The title compound was prepared by the method of example 1 step (ii) and step (iii) using the product from example 1 step (i) and 4-carboxyphenylboronic acid. Yield 0.035 g

Sources & evidence

ORD record: ord-a217f0a4c4984fa58cdcc73cbaaad922
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08158820B2

Reaction notes

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