4-Ethylthiophenylboronic acid → 2-[[5-Chloro-4'-(ethylthio)[1,1'-biphenyl]-2-yl]oxy]-propanoic acid, 1,1-dimethylethyl ester
Reaction equation
Br[C:2]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:3]=1[O:4][CH:5]([CH3:13])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7].[CH2:19]([S:21][C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1)[CH3:20]>>[Cl:18][C:16]1[CH:15]=[CH:14][C:3]([O:4][CH:5]([CH3:13])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])=[C:2]([C:25]2[CH:26]=[CH:27][C:22]([S:21][CH2:19][CH3:20])=[CH:23][CH:24]=2)[CH:17]=1Participants
3
Procedure
The subtitle compound was prepared by the method of example 1 step (ii) using the product from step (i) and 4-(ethylthio)benzeneboronic acid, yield 1.2 g.
Sources & evidence
- ORD record
- ord-131890eda6ae47a8b4f5cdc60705d0cb
- Source dataset
- uspto-grants-2012_04