HCID 17887686, compound → 3-(Difluoromethoxy)-β-oxobenzenepropanenitrile

Reaction equation

[NH2:1][C:2]1[CH:6]=CNN=1.COC(=O)C1C=CC(OCC2CC2)=C(Cl)C=1.CO[C:25](=[O:36])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH:33]([F:35])[F:34])[CH:27]=1>>[F:35][CH:33]([F:34])[O:32][C:28]1[CH:27]=[C:26]([C:25](=[O:36])[CH2:6][C:2]#[N:1])[CH:31]=[CH:30][CH:29]=1

Participants

Reactant 3

HCID 17887686HCID 17887686, compound

HCID 67015924HCID 67015924, compound

HCID 178418806HCID 178418806, compound

Product 1

HCID 431238303-(Difluoromethoxy)-β-oxobenzenepropanenitrile

Procedure

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1 bis) from 3-difluoromethoxy-benzoic acid methyl ester (1.5 g, 7.4 mmol, 1.0 eq). The crude was precipitated by addition of aqueous HCl to give the product which was used directly for the next step.