3,3-Dimethylbutylamine → HCID 178483753, compound

HRID 1695936Notes

Reaction equation

HRID 1695936 reaction equation
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][NH:5][C:6]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:7]=1[CH:8]=O.[CH3:16][C:17]([CH3:22])([CH3:21])[CH2:18][CH2:19][NH2:20]>C1(C)C=CC=CC=1>[CH3:16][C:17]([CH3:22])([CH3:21])[CH2:18][CH2:19]/[N:20]=[CH:8]/[C:7]1[CH:10]=[CH:11][CH:12]=[C:13]([F:14])[C:6]=1[NH:5][CH2:4][CH2:3][N:2]([CH3:15])[CH3:1]

Participants

4

Reactant 2

HCID 197093,3-DimethylbutylamineHCID 577744202-(2-(Dimethylamino)ethylamino)-3-fluorobenzaldehyde

Product 1

HCID 178483753HCID 178483753, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2-(2-(Dimethylamino)ethylamino)-3-fluorobenzaldehyde (157 mg, 0.7467 mmol) and 3,3-dimethylbutan-1-amine (150 μL, 1.115 mmol) were stirred at RT in toluene (5 mL) with 4 Å MS overnight. The suspension was filtered and volatiles removed on a rotary evaporator at 40° C. 1H-NMR was consistent with 2-((E)-(3,3-dimethylbutylimino)methyl)-N-(2-(dimethylamino)ethyl)-6-fluorobenzenamine (175 mg). The crude product was carried on to next reaction.

Workup

  1. filtrationThe suspension was filtered
  2. customvolatiles removed on a rotary evaporator at 40° C
  3. customThe crude product was carried on to next reaction

Sources & evidence

ORD record
ord-b7f4050ddfb8416b9c23067e00327909
Source dataset
uspto-grants-2012_04
Patent number
US08163737B2

Reaction notes

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