[C:1]([O:5][C:6]([N:8]1[CH2:13][C@@H:12]2[CH2:14][C@H:9]1[CH2:10][N:11]2[C:15]1[N:24]=[C:23]2[C:18]([C:19](=[O:41])[C:20]([C:36]([O:38]CC)=[O:37])=[CH:21][N:22]2[CH2:25][C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=2[O:34][CH3:35])=[CH:17][C:16]=1[F:42])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl-].[NH4+]>C(O)C>[C:1]([O:5][C:6]([N:8]1[CH2:13][C@@H:12]2[CH2:14][C@H:9]1[CH2:10][N:11]2[C:15]1[N:24]=[C:23]2[C:18]([C:19](=[O:41])[C:20]([C:36]([OH:38])=[O:37])=[CH:21][N:22]2[CH2:25][C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=2[O:34][CH3:35])=[CH:17][C:16]=1[F:42])=[O:7])([CH3:4])([CH3:2])[CH3:3]A solution of EXAMPLE 84A in 1:1 ethanol/1M NaOH (20 mL) was heated at 80° C. for 18 hours then cooled, poured into saturated ammonium chloride (100 mL), and filtered.
Loading…