4-Iodo-2-(trifluoromethyl)pyridine → (S)-Methyl2-(tert-butoxycarbonyl)-3-(2-(trifluoromethyl)pyridin-4-yl)propanoate

HRID 1697184

Reaction equation

HRID 1697184 reaction equation
[C:1]([O:5][C:6]([C@H:8]([CH2:13]I)[C:9]([O:11][CH3:12])=[O:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].I[C:16]1[CH:21]=[CH:20][N:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=1>>[C:1]([O:5][C:6]([C@@H:8]([CH2:13][C:16]1[CH:21]=[CH:20][N:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=1)[C:9]([O:11][CH3:12])=[O:10])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 234369404-Iodo-2-(trifluoromethyl)pyridineHCID 86614124(R)-methyl2-(tert-butoxycarbonyl)-3-iodopropanoate

Product 1

HCID 67165305(S)-Methyl2-(tert-butoxycarbonyl)-3-(2-(trifluoromethyl)pyridin-4-yl)propanoate

Procedure

The title compound was prepared according to previously reported procedure (see pending U.S. patent application Ser. No. 11/575,187) from (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 4-iodo-2-(trifluoromethyl)pyridine (this starting material was prepared according to a procedure described in Eur. J. Org. Chem. 2003, 1559-1568).

Sources & evidence

ORD record
ord-cbebf66771c04952bc7e7dd7c5332e4f
Source dataset
uspto-grants-2012_04
Patent number
US08163909B2

Linked notes

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