Methanesulfonate → (2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-(2,6-dichloro-phenylsulfanyl)-pyrrolidine-1-carboxylic acid t-butyl ester
Reaction equation
S([O-])(=O)(=O)C.[C:6]([O:10][C:11]([N:13]1[CH2:17][C@@H:16](OS(C)(=O)=O)[CH2:15][C@H:14]1[C:23](=[O:30])[NH:24][C:25]1([C:28]#[N:29])[CH2:27][CH2:26]1)=[O:12])([CH3:9])([CH3:8])[CH3:7].[Cl:31][C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[C:33]=1[SH:39]>>[C:6]([O:10][C:11]([N:13]1[CH2:17][C@H:16]([S:39][C:33]2[C:34]([Cl:38])=[CH:35][CH:36]=[CH:37][C:32]=2[Cl:31])[CH2:15][C@H:14]1[C:23](=[O:30])[NH:24][C:25]1([C:28]#[N:29])[CH2:27][CH2:26]1)=[O:12])([CH3:8])([CH3:9])[CH3:7]Participants
4
Reactant 3
Product 1
Procedure
The reaction of the mesylate from experiment A2 with 2,6-dichlorothiophenol yielded (2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-(2,6-dichloro-phenylsulfanyl)-pyrrolidine-1-carboxylic acid t-butyl ester as a white solid. MS: 454.4 [M−H]−.