1-Methylpiperidine-4-carboxylic acid → HCID 46947785, compound
Reaction equation
Cl.[C:2]([C:4]1([NH:7][C:8]([C@@H:10]2[CH2:14][C@@H:13]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])(=[O:17])=[O:16])[CH2:12][NH:11]2)=[O:9])[CH2:6][CH2:5]1)#[N:3].[CH3:25][N:26]1[CH2:31][CH2:30][CH:29]([C:32](O)=[O:33])[CH2:28][CH2:27]1>>[C:2]([C:4]1([NH:7][C:8]([C@@H:10]2[CH2:14][C@@H:13]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])(=[O:17])=[O:16])[CH2:12][N:11]2[C:32]([CH:29]2[CH2:30][CH2:31][N:26]([CH3:25])[CH2:27][CH2:28]2)=[O:33])=[O:9])[CH2:6][CH2:5]1)#[N:3]Participants
3
Procedure
L31. (2S,4R)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide hydrochloride from experiment K4 was coupled with 1-methyl-piperidine-4-carboxylic acid in analogy to experiment A1 to give (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(1-methyl-piperidine-4-carbonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide as a white solid. MS: 479.1 [M+H]+.
Sources & evidence
- ORD record
- ord-cbd33395bfd9454e800e47347571f8c4
- Source dataset
- uspto-grants-2012_04