(Oxan-4-yl)hydrazine hydrochloride → HCID 67278353, compound

HRID 1697592

Reaction equation

HRID 1697592 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23](=S)[CH2:24][C:25](=O)[CH3:26])=[O:4].Cl.[O:30]1[CH2:35][CH2:34][CH:33]([NH:36][NH2:37])[CH2:32][CH2:31]1>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:11])=[O:12])[CH2:7][N:6]1[C:23]1[N:36]([CH:33]2[CH2:34][CH2:35][O:30][CH2:31][CH2:32]2)[N:37]=[C:25]([CH3:26])[CH:24]=1)=[O:4]

Participants

3

Reactant 2

HCID 17773358(Oxan-4-yl)hydrazine hydrochlorideHCID 86646823(2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

Product 1

HCID 67278353HCID 67278353, compound

Procedure

In analogy to the procedure described in example 192 h, (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192 g) was reacted with (tetrahydropyran-4-yl)hydrazine hydrochloride (CAS Reg. No. 194543-22-1) to give the title compound as orange oil. MS (ESI): m/z=502.1 [M+H]+.

Sources & evidence

ORD record
ord-92ddfea7f6dd419bb5414b87d81b19d7
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Linked notes

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