(Oxan-4-yl)hydrazine hydrochloride → HCID 67278636, compound

HRID 1697672

Reaction equation

HRID 1697672 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[C:20]([F:23])([F:22])[F:21])(=[O:12])=[O:11])[CH2:7][N:6]1[C:24](=S)[CH2:25][C:26](=O)[CH3:27])=[O:4].Cl.[O:31]1[CH2:36][CH2:35][CH:34]([NH:37][NH2:38])[CH2:33][CH2:32]1>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[C:20]([F:23])([F:21])[F:22])(=[O:11])=[O:12])[CH2:7][N:6]1[C:24]1[N:37]([CH:34]2[CH2:35][CH2:36][O:31][CH2:32][CH2:33]2)[N:38]=[C:26]([CH3:27])[CH:25]=1)=[O:4]

Participants

3

Reactant 2

HCID 17773358(Oxan-4-yl)hydrazine hydrochlorideHCID 86646829(2S,4R)-4-(4-Fluoro-2-trifluoromethyl-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic Acid Methyl Ester

Product 1

HCID 67278636HCID 67278636, compound

Procedure

In analogy to the procedure described in example 192 h, (2S,4R)-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester (example 388 d) was reacted with (tetrahydro-pyran-4-yl)-hydrazine hydrochloride (CAS Reg. No. 116312-69-7) to give the title compound as brown solid. MS (ESI): m/z=520.3 [M+H]+.

Sources & evidence

ORD record
ord-8dfdf928a1d948a1963c4d24d4e862fb
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Linked notes

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