Glycerol → Bupivacaine (USAN:INN:BAN)

HRID 1699646

Reaction equation

HRID 1699646 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.OCC(CO)O>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

Participants

4

Reactant 2

HCID 753GlycerolHCID 64737Bupivacaine Hydrochloride

Product 1

HCID 2474Bupivacaine (USAN:INN:BAN)

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A composition suitable for administration in vaginal suppository form la prepared by weighing 2 mg of finely divided polynucleotide medicinal substance into a tared container, adding 10 ml of 0.5% bupivacaine HCl in purified water, to make a total of 10 g, and dissolving or mixing depending on the solubility of the medicinal substance; 70 g of glycerin is added and mixed; 20 g of granular gelatin is then added and the composition heated carefully on a steam bath until the gelatin is dissolved. The melted mixture is poured into chilled molds to yield 20 vaginal suppositories of 6 grams each containing 100 mcg of polynucleotide medicinal substance in admixture with 2.5 mg bupivacaine.

Workup

  1. customA composition suitable for administration in vaginal suppository form la prepared
  2. dissolutiondissolving
  3. additionmixing
  4. additionmixed
  5. addition20 g of granular gelatin is then added
  6. temperaturethe composition heated carefully on a steam bath until the gelatin
  7. dissolutionis dissolved
  8. additionThe melted mixture is poured
  9. temperatureinto chilled molds

Sources & evidence

ORD record
ord-6611d185663e46d5851fc4871102833d
Source dataset
uspto-grants-2002_02
Patent number
US06348449B1

Linked notes

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