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Ethanol → HCID 178435252, compound

HRID 1700150
Notes
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Reaction equation

HRID 1700150 reaction equation
CN(C)[CH:3]1[C:14]2[C:6](=[CH:7][CH:8]=[C:9]3[C:13]=2[S:12](=C)[CH:11]=[N:10]3)[NH:5][C:4]1=[O:16].[CH3:18][CH2:19][C:20]1([C:28]2[CH:33]=[CH:32][C:31]([NH2:34])=[CH:30][CH:29]=2)[C:26](=[O:27])[NH:25][C:23](=[O:24])[CH2:22][CH2:21]1.[CH2:35](O)C>C(OCC)C>[CH2:19]([C:20]1([C:28]2[CH:29]=[CH:30][C:31]([NH:34]/[CH:35]=[C:3]3\[C:4](=[O:16])[NH:5][C:6]4[C:14]\3=[C:13]3[S:12][CH:11]=[N:10][C:9]3=[CH:8][CH:7]=4)=[CH:32][CH:33]=2)[CH2:21][CH2:22][C:23](=[O:24])[NH:25][C:26]1=[O:27])[CH3:18]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 702Ethanol2×HCID 2145AminoglutethimideHCID 865855238-Dimethylamino-methylene-6,8-dihydro-1-thia-3,6diaza-as-indacen-7one

Product 1

HCID 178435252HCID 178435252, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 8-dimethylamino-methylene-6,8-dihydro-1-thia-3,6-diaza-as-indacen-7-one (Procedure E, 0.040 g, 0.163 mmol), DL-aminoglutethimide (0.055 g, 0.237 mmol) in absolute ethanol (5 ml) was heated with stirring at 90° C. for 16 h. The reaction was diluted with ethanol and diethyl ether and the product collected by filtration to yield 0.038 g (54%) of the title compound.

Workup

  1. temperaturewas heated
  2. filtrationthe product collected by filtration

Sources & evidence

ORD record
ord-6d976f46b92244b497a1625113797ff8
Source dataset
uspto-grants-2002_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06350747B1

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes