2,3,5,6-Tetrafluoro-4-(1,3-difluoroprop-2-oxy)pyridine → 2,3,5,6-Tetrafluoro-4-methoxypyridine

Reaction equation

[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10]C(F)(F)F)[C:5]([F:15])=[C:4]([F:16])[N:3]=1.FC1C(F)=C(OC(CF)CF)C(F)=C(F)N=1>>[CH3:10][O:9][C:6]1[C:7]([F:8])=[C:2]([F:1])[N:3]=[C:4]([F:16])[C:5]=1[F:15]

Participants

Reactant 2

HCID 234421362,3,5,6-Tetrafluoro-4-(1,3-difluoroprop-2-oxy)pyridine

HCID 234421762,3,5,6-Tetrafluoro-4-(2,2,2-trifluoroethoxy)pyridine

Product 1

HCID 139996172,3,5,6-Tetrafluoro-4-methoxypyridine

Procedure

In a similar manner, the following compounds were made: 2,3,5,6-tetrafluoro-4-(2,2,2-trifluoroethoxy)pyridine; and 2,3,5,6-tetrafluoro-4-(1,3-difluoroprop-2-oxy)pyridine.

Sources & evidence

ORD record: ord-2375dc3f7c8c4c709ac745043c46a605
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06350746B1

Reaction notes

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