Bromine → alpha-Bromo-3-chloropropiophenone

HRID 17016

Reaction equation

HRID 17016 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:11])[CH2:9][CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:12]Br>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:11])[CH:9]([Br:12])[CH3:10])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 24408Bromine2×HCID 5871283'-Chloropropiophenone

Product 1

HCID 4992116alpha-Bromo-3-chloropropiophenone

Procedure

To 1 mole of m-chloropropiophenone heated to 60±5° C., bromine was added dropwise under stirring. The reaction temperature was kept at 60±5° C. during the addition of bromine, and kept for 5.5 hours after the addition. m-Chloro-α-bromopropiophenone (compound of formula (II)) was obtained.

Workup

  1. additionafter the addition

Sources & evidence

ORD record
ord-82d524a4fede43a787b399d1de854e8d
Source dataset
uspto-grants-2010_06
Patent number
US07737302B2

Linked notes

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