Morpholine → 4-(3-Chloropyrazin-2-YL)morpholine

HRID 1701734

Reaction equation

HRID 1701734 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>O>[Cl:8][C:7]1[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[N:3][CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 785752,3-Dichloropyrazine

Product 1

HCID 205289944-(3-Chloropyrazin-2-YL)morpholine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

149 g of 2,3-dichloropyrazine, 300 g of morpholine and 400 ml of water are stirred for 16 hours at 40° C. The reaction mixture is then extracted by shaking with ether. The ether extracts are washed with water until neutral, dried over sodium sulphate and evaporated in a waterpump vacuum. The residue is distilled in a waterpump vacuum. 2-Chloro-3-morpholinyl-pyrazine, boiling point 162°-165° C./15 mm Hg, is thus obtained.

Workup

  1. extractionThe reaction mixture is then extracted
  2. washThe ether extracts are washed with water until neutral,
  3. dry with materialdried over sodium sulphate
  4. customevaporated in a waterpump vacuum
  5. distillationThe residue is distilled in a waterpump vacuum

Sources & evidence

ORD record
ord-98503fab6c624f5d9887220362d60b3c
Source dataset
uspto-grants-1980_03
Patent number
US04195090

Linked notes

Loading…