2-Amino-5-Nitrothiazole → 3-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide

HRID 1701833

Reaction equation

HRID 1701833 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](Cl)=[O:8])([O-:3])=[O:2].[NH2:13][C:14]1[S:15][C:16]([N+:19]([O-:21])=[O:20])=[CH:17][N:18]=1>N1C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH:13][C:14]1[S:15][C:16]([N+:19]([O-:21])=[O:20])=[CH:17][N:18]=1)=[O:8])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 84862-Amino-5-NitrothiazoleHCID 8495Benzoyl chloride, 3-nitro-

Product 1

HCID 2989303-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

By following the procedure of the first part of Example 1, but using m-nitrobenzoyl chloride (27.8 g), 2-amino-5-nitrothiazole (21.8 g) and pyridine (100 ml), there was obtained 3-nitro-N-(5-nitro-2-thiazolyl)benzamide, m.pt 200°-201°, after recrystallisation from acetic acid.

Sources & evidence

ORD record
ord-869f3175addf4932a6aa8edebdad26e4
Source dataset
uspto-grants-1983_04
Patent number
US04379156

Linked notes

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