Bromine → alpha-Bromo-3-chloropropiophenone

HRID 17020

Reaction equation

HRID 17020 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:11])[CH2:9][CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:12]Br>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=[O:11])[CH:9]([Br:12])[CH3:10])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 24408Bromine2×HCID 5871283'-Chloropropiophenone

Product 1

HCID 4992116alpha-Bromo-3-chloropropiophenone

Procedure

To 1 mole of m-chloropropiophenone heated to 85±5° C., bromine was added dropwise under stirring. The reaction temperature was kept at 85±5° C. during and after the addition of bromine, and the reaction was carried on for 2 hours. Then m-chloro-α-bromopropiophenone (compound of formula (II)) was obtained.

Workup

  1. customwas kept at 85±5° C.
  2. customwas carried on for 2 hours

Sources & evidence

ORD record
ord-f3db7bb05d2f478a806fe6b5641ed89b
Source dataset
uspto-grants-2010_06
Patent number
US07737302B2

Linked notes

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