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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1702437Generated: October 26, 2026

Thionyl Chloride → N-(2-Chloro-3-pyridinyl)-1-methyl-4-nitro-1H-pyrazole-5-carboxamide

https://huagongshe.com/reaction/1702437

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant2-Chloro-3-pyridylamineHCID 80528—
Reactant1-Methyl-4-nitro-1H-pyrazole-5-carboxylic acidHCID 592623—
SolventHexamethylphosphoramideHCID 12679—
ProductN-(2-Chloro-3-pyridinyl)-1-methyl-4-nitro-1H-pyrazole-5-carboxamideHCID 20503812—

Reaction Steps

Prepared analogously to Example A(a) from 1-methyl-4-nitro-1H-pyrazole-5-carboxylic acid, thionyl chloride, and 2-chloro-3-aminopyridine in hexamethylphosphoric acid triamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04381303
Source datasetuspto-grants-1983_04
ORD IDord-b2a0c8d53a49410a83030612c2642573
Source noteuspto-grants-1983_04