Thionyl Chloride → HCID 178479468, compound

HRID 1702609

Reaction equation

HRID 1702609 reaction equation
[ClH:1].[NH:2]([CH2:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([C:13]([OH:15])=O)[CH2:9][CH2:8]1)[C:3]([NH2:5])=[NH:4].S(Cl)([Cl:18])=O>>[ClH:18].[NH:2]([CH2:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([C:13]([Cl:1])=[O:15])[CH2:9][CH2:8]1)[C:3]([NH2:5])=[NH:4]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 178479474HCID 178479474, compound

Product 1

HCID 178479468HCID 178479468, compound

Procedure

A suspension of trans-4-guanidinomethylcyclohexanecarboxylic acid hydrochloride (1.2 g) and thionyl chloride (15 ml) was stirred at room temperature for 3 hours. Thereafter, excess thionyl chloride was removed by distillation under reduced pressure. The residue was washed with anhydrous ethyl ether to obtain trans-4-guanidinomethylcyclohexanecarboxylic acid chloride hydrochloride (1.2 g) as colorless powder.

Workup

  1. customThereafter, excess thionyl chloride was removed by distillation under reduced pressure
  2. washThe residue was washed with anhydrous ethyl ether

Sources & evidence

ORD record
ord-d9af0aa0853d4105a0fad7c3b8b7641c
Source dataset
uspto-grants-1982_09
Patent number
US04348410

Linked notes

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