Ethylamine → 2-(Ethylamino)nicotinonitrile
Reaction equation
Cl[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH2:10]([NH2:12])[CH3:11]>O>[CH2:10]([NH:12][C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A stirred mixture of 4 g. of 2-chloronicotinonitrile in 200 ml. of a saturated ethanolic ethylamine solution was heated under reflux for 5 hours. The solution was cooled and was diluted with 400 ml. of water. The precipitate of 2-ethylaminonicotinonitrile which formed was collected, air dried and was used directly in the next step without further purification.
Workup
- additionA stirred mixture of 4 g
- temperatureunder reflux for 5 hours
- temperatureThe solution was cooled
- additionwas diluted with 400 ml
Sources & evidence
- ORD record
- ord-ac1fbfe4d7ad40b196c483929ecd5e01
- Source dataset
- uspto-grants-1982_09
- Patent number
- US04350817
Reaction notes
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