Ammonia → 1-Methyl-1,5-dihydropyrazolo(3,4-d)pyrimidin-4-one
Reaction equation
C(O[CH:4]=[N:5][C:6]1[N:10]([CH3:11])[N:9]=[CH:8][C:7]=1[C:12]([O:14]CC)=O)C.[NH3:17]>C(O)C>[CH3:11][N:10]1[C:6]2[N:5]=[CH:4][NH:17][C:12](=[O:14])[C:7]=2[CH:8]=[N:9]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
57.2 g. of 5 -[(ethoxymethylene)amino]-1-methyl-1H- pyrazole-4-carboxylic acid, ethyl ester are dissolved in 200 ml. of ethanol, 4.4 g. of ammonia are added and the reaction mixture is autoclaved at 60° for 40 hours. After cooling, the mixture is filtered and the residual 1-methyl-1,5-dihydro-4H-pyrazolo- [3,4-d]pyrimidin-4-one is crystallized from dimethylformamide, m.p. 289°-290° (yield 31 g. - 80.7%).
Workup
- temperatureAfter cooling
- filtrationthe mixture is filtered
- customthe residual 1-methyl-1,5-dihydro-4H-pyrazolo- [3,4-d]pyrimidin-4-one is crystallized from dimethylformamide, m.p. 289°-290° (yield 31 g. - 80.7%)
Sources & evidence
- ORD record
- ord-c4a8444eb5b24fa99e2c6e965916e8f7
- Source dataset
- uspto-grants-1978_11
- Patent number
- US04124764
Reaction notes
Loading…