Reaction equation
[ClH:1].[C:2]1([CH:8]2[CH2:12][CH2:11][CH2:10][CH:9]2[NH2:13])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14](O)[CH3:15]>>[ClH:1].[CH3:8][CH:9]1[NH:13][C:15](=[N:13][CH:9]2[CH2:10][CH2:11][CH2:12][CH:8]2[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:14][CH2:10]1Participants
3
Conditions
- Temperature
- -20 °C
Procedure
A slurry of 3.0 g (0.0152 mole) of powdered 2-phenylcyclopentylamine hydrochloride and 3 ml of 5,O-dimethylbutyrolactim is allowed to stand at room temperature for 6 days with occasional stirring during which time sufficient ethanol is added to maintain the slurry. The slurry is then cooled to -20° C., and after about four hours a precipitate forms. The precipitate is collected and recrystallized several times from acetone-methanol to give 5-methyl-2-[(2-phenylcyclopentyl)imino]pyrrolidine hydrochloride, M.P. 175°-178° C.
Workup
- additionis added
- temperatureto maintain the slurry
- waitafter about four hours a precipitate forms
- customThe precipitate is collected
- customrecrystallized several times from acetone-methanol
Sources & evidence
- ORD record
- ord-957b35170c5347dea6093ae48de65c75
- Source dataset
- uspto-grants-1978_11
- Patent number
- US04126613
Linked notes
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