3-(Dimethylamino)propyl chloride hydrochloride → Dimaprit hydrochloride
Reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[ClH:5].[CH3:6][N:7]([CH3:12])[CH2:8][CH2:9][CH2:10][Cl:11]>C(O)C>[ClH:11].[ClH:5].[CH3:6][N:7]([CH3:12])[CH2:8][CH2:9][CH2:10][S:3][C:2](=[NH:4])[NH2:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Equimolar quantities of thiourea and 3-(dimethylamino)-1-chloropropane hydrochloride and a little ethanol are heated together at 140° for 3 hours, and the cooled mixture is recrystallised from methanol/isopropanol to give the title product.
Workup
- customthe cooled mixture is recrystallised from methanol/isopropanol
Sources & evidence
- ORD record
- ord-9062996cf30a4f2d8df7903bf697b00e
- Source dataset
- uspto-grants-1978_11
- Patent number
- US04126670
Reaction notes
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