Sulfuric Acid → Valpromide

Reaction equation

[CH2:1]([CH:4]([CH2:7][CH2:8][CH3:9])[C:5]#[N:6])[CH2:2][CH3:3].S(=O)(=O)(O)[OH:11]>>[CH2:1]([CH:4]([CH2:7][CH2:8][CH3:9])[C:5]([NH2:6])=[O:11])[CH2:2][CH3:3]

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 833302-Propylvaleronitrile

Product 1

HCID 71113Valpromide

Procedure

Process according to claim 1, whereby the di-n-propyl acetonitrile is hydrolysed by means of 75% aqueous sulphuric acid in the proportion of 1.7 g of dilute acid/g of nitrile at the temperature of 140° C. and then the crude di-n-propyl acetamide thus obtained is hydrolysed in the same aqueous sulphuric acid medium in the presence of 1.4 to 1.5 mol of sodium nitrite/mol of nitrile at a temperature of 50°-60° C.

Sources & evidence

ORD record: ord-bc44fc58772c46f59a54cf07ee4aa09b
Source dataset: uspto-grants-1978_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04127604

Reaction notes

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