Chlorine → Butanamide, 2-chloro-N-methyl-3-oxo-

HRID 1706345

Reaction equation

[CH3:1][NH:2][C:3](=[O:8])[CH2:4][C:5]([CH3:7])=[O:6].[Cl:9]Cl>>[CH3:1][NH:2][C:3](=[O:8])[CH:4]([Cl:9])[C:5]([CH3:7])=[O:6]

Participants

Reactant 2

HCID 24526Chlorine

HCID 88483N-Methylacetoacetamide

Product 1

HCID 20065Butanamide, 2-chloro-N-methyl-3-oxo-Yield 97.4%

Procedure

Altogether, the aqueous phase was subjected to chlorination five times. A total of 492 parts by weight of N-methylacetoacetamide (MMAA) of 99.5% strength, and 283.5 parts by weight of chlorine were used, and altogether 588.6 parts by weight of 97.4% N-methyl-α-chloracetoacetamide (MMCAA) were obtained, that is, 96.8% of the theoretical yield, calculated on reacted MMAA.

Sources & evidence

ORD record: ord-98d701b02df64754a597f1c35a67078e
Source dataset: uspto-grants-1980_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04207259

Linked notes

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