Carbamic acid, ethyl ester → Methyl 2-[(ethoxycarbonyl)amino]-1-cycloheptene-1-carboxylate

Reaction equation

O=[C:2]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[C:9]([O:11][CH3:12])=[O:10].[NH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]>>[CH2:17]([O:16][C:14]([NH:13][C:2]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]=1[C:9]([O:11][CH3:12])=[O:10])=[O:15])[CH3:18]

Participants

Reactant 2

HCID 5641Carbamic acid, ethyl ester

HCID 288225Methyl 2-oxocycloheptane-1-carboxylate

Product 1

HCID 53887984Methyl 2-[(ethoxycarbonyl)amino]-1-cycloheptene-1-carboxylate

Procedure

Using the method of Example 1 Part A, methyl 2-oxocycloheptanecarboxylate (50.5 g, 0.30 mole) was reacted with urethane to provide 59 g of methyl 2-[(ethoxycarbonyl)amino]-1-cycloheptene-1-carboxylate as an oil.

Sources & evidence

ORD record: ord-187968695fd7497695c108d0bbe3bfa5
Source dataset: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05352784

Reaction notes

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