Sodium Methoxide → Methyl 2-amino-1-cycloheptene-1-carboxylate

Reaction equation

C(OC([NH:6][C:7]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]=1[C:14]([O:16][CH3:17])=[O:15])=O)C.C[O-].[Na+]>>[NH2:6][C:7]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]=1[C:14]([O:16][CH3:17])=[O:15]

Participants

Reactant 2

HCID 10942334Sodium Methoxide

HCID 53887984Methyl 2-[(ethoxycarbonyl)amino]-1-cycloheptene-1-carboxylate

Product 1

HCID 53894859Methyl 2-amino-1-cycloheptene-1-carboxylateYield 73.9%

Procedure

Using the method of Example 1 Part B, methyl 2-[(ethoxycarbonyl)amino]-1-cycloheptene-1-carboxylate (59 g, 0.24 mole) was reacted with sodium methoxide to provide 30 g of methyl 2-amino-1-cycloheptene-1-carboxylate as an off white solid.

Sources & evidence

ORD record: ord-a00aaeca3829428ca1baf07c54fad82d
Source dataset: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05352784

Reaction notes

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