HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1708024Generated: October 24, 2026
Sulfur → 2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine
https://huagongshe.com/en/reaction/1708024
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfur | HCID 5362487 | — |
| Reactant | 3-(1-Acetyl-l,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine | HCID 19957261 | — |
| Solvent | Decalin | HCID 7044 | — |
| Product | 2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine | HCID 19957277 | 49.1% |
Reaction Steps
A mixture of 3-(1-acetyl-1,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine (315 mg) and sulfur (146 mg) in decaline (3 ml) was stirred at 190° C. for 2 hours. The reaction mixture was cooled and purified by column chromatography on silica gel to give 2-(4-fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine (135 mg) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05356897 |
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| Source dataset | uspto-grants-1994_10 |
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| ORD ID | ord-e456eb84833d49f0858b35c8c7319e96 |
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| Source note | uspto-grants-1994_10 |
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