Sodium pidolate → HCID 23682097, compound

Reaction equation

[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([O-:9])=[O:8].[Na+:10].N1C(=[O:16])CC[C@@H]1C([O-])=O.[Na+]>>[OH2:6].[OH2:16].[OH2:6].[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([O-:9])=[O:8].[Na+:10]

Participants

Reactant 2

HCID 23668602Sodium pidolate

HCID 23714632Sodium 5-oxo-D-prolinate

Product 1

HCID 23682097HCID 23682097, compound

Procedure

A mixture of 85 mole % sodium L-pyroglutamate and 15 mole % sodium D-pyroglutamate crystallized in a manner analogous to Example 6. 12% of theory sodium L-pyroglutamate trihydrate was obtained at a concentration of 60% in the solution during cooling to -10° C.

Workup

customcrystallized in a manner analogous to Example 6

Sources & evidence

ORD record: ord-b19a5842c94d4695a3d02821a15e0c70
Source dataset: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04952706

Reaction notes

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