Methyl iodide → HCID 178503353, compound
Reaction equation
[CH3:1][I:2].[Cl:3][C:4]1[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]2[C:5]=1[CH:6]([CH3:16])[NH:7][C:8](=[S:15])[NH:9]2>CC(C)=O.C(OCC)C>[IH:2].[Cl:3][C:4]1[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]2[C:5]=1[CH:6]([CH3:16])[NH:7][C:8]([S:15][CH3:1])=[N:9]2Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
Methyl iodide (0.73 ml, 11.7 mmol) was added to a suspension of 5,8-dichloro-4-methyl-3,4-dihydro-1H-quinazoline-2-thione (0.96 g, 3.9 mmol) in acetone (12 ml), and the mixture was stirred at room temperature overnight. The reaction was diluted with diethyl ether, and the precipitated product (1.31 g, 86%) was isolated by filtration as a white solid.
Sources & evidence
- ORD record
- ord-dce822a163894ec5af59f7c95825da56
- Source dataset
- uspto-grants-2010_09
- Patent number
- US07790732B2
Reaction notes
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