Sodium Hydroxide → (Pyridin-2-ylsulfanyl)-acetic acid

HRID 1711128Notes

Reaction equation

HRID 1711128 reaction equation
C[O:2][C:3](=[O:12])[CH2:4][S:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1.[OH-].[Na+]>CO>[N:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[S:5][CH2:4][C:3]([OH:12])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15388132Methyl 2-pyridin-2-ylsulfanylacetate

Product 1

HCID 654661(Pyridin-2-ylsulfanyl)-acetic acidYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the ester from above (751 mg, 4.10 mmol) in MeOH (50 ml) and 1N NaOH (10 ml) was stirred at room temperature for 45 minutes to give (pyridin-2-ylsulfanyl)-acetic acid (655 mg, 95%) after acidic work-up.

Sources & evidence

ORD record
ord-2253ce553bff44268f3d42805d563042
Source dataset
uspto-grants-2010_09
Patent number
US07790747B2

Reaction notes

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