Benzoic acid, 2-hydroxy-4-methyl-, methyl ester → HCID 68503596, compound

Reaction equation

[OH:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].Cl[CH2:14][CH2:15][CH2:16][O:17][CH3:18]>>[CH3:18][O:17][CH2:16][CH2:15][CH2:14][O:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

Participants

Reactant 2

HCID 78400Benzoic acid, 2-hydroxy-4-methyl-, methyl ester

HCID 1189271-Chloro-3-methoxypropane

Product 1

HCID 68503596HCID 68503596, compound

Procedure

Analogously to Method F, 103.7 g of methyl 2-hydroxy-4-methylbenzoate are reacted with 95.8 g of 1-chloro-3-methoxypropane. The title compound is obtained as slightly beige oil. Rf=0.27 (1:2 EtOAc-heptane); Rt=4.22.

Sources & evidence

ORD record: ord-293529afbdaa4a4183a38d529f811ca6
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790715B2

Reaction notes

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