1-Chloro-3-methoxypropane → 1-Ethoxy-2-(3-methoxypropoxy)-4-methylbenzene

Reaction equation

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[OH:11])[CH3:2].Cl[CH2:13][CH2:14][CH2:15][O:16][CH3:17]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[O:11][CH2:13][CH2:14][CH2:15][O:16][CH3:17])[CH3:2]

Participants

Reactant 2

HCID 1189271-Chloro-3-methoxypropane

HCID 122571232-Ethoxy-5-methylphenol

Product 1

HCID 592240741-Ethoxy-2-(3-methoxypropoxy)-4-methylbenzene

Procedure

Analogously to Method F, 5.05 g of 2-ethoxy-5-methylphenol and 4.03 g of 1-chloro-3-methoxypropane are reacted. The title compound is obtained as a slightly orange oil. Rf=0.32 (1:4 EtOAc-heptane); Rt=4.60

Sources & evidence

ORD record: ord-6d574666e20d46d3ab5e71c4a92868eb
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790715B2

Reaction notes

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