3-Methoxysalicyl alcohol → [3-Methoxy-2-(2-methoxyethoxy)phenyl]methanol

HRID 1712470

Reaction equation

HRID 1712470 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[OH:11].[CH3:12][O:13][CH2:14][CH2:15]Br>>[CH3:10][O:9][C:5]1[C:4]([O:11][CH2:15][CH2:14][O:13][CH3:12])=[C:3]([CH2:2][OH:1])[CH:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 780883-Methoxysalicyl alcoholHCID 809722-Bromoethyl methyl ether

Product 1

HCID 43471496[3-Methoxy-2-(2-methoxyethoxy)phenyl]methanol

Procedure

Analogously to Method F, 2.44 g of 2-hydroxymethyl-6-methoxyphenol and 2.56 g of 2-bromoethyl methyl ether are reacted and the title compound is obtained as a colourless oil. Rf=0.22 (1:1 EtOAc-heptane); Rt=2.91.

Sources & evidence

ORD record
ord-0cb7def840b645229323f33e3cd3afba
Source dataset
uspto-grants-2010_09
Patent number
US07790715B2

Linked notes

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